General Proximity

generalproximity.bio · Healthcare

8open roles

0new in 30 days

0closed in 30 days

0remote-eligible

freezehiring velocity

What they're building

Hit-to-lead and lead optimization of bifunctional induced proximity medicines (IPMs), including PROTACs strong signal

Today: "We've built the first generalized, mechanism-agnostic, proximity discovery engine" (site); postings call it the OmniTAC drug discovery engine.

Roles: Scientist, Medicinal Chemistry · Sr. Scientist/Principal Scientist, Medicinal Chemistry · Scientist/Sr. Scientist, Chemical Biology

Requirements mention: "hit-to-lead and lead optimization", "induced proximity medicines" and "PROTACs" (Scientist, Medicinal Chemistry) · "hit-to-lead", "lead optimization", "SAR campaigns" and "PROTACs" (Sr. Scientist/Principal Scientist, Medicinal Chemistry) · "hit-to-lead" and "lead optimization" (Scientist/Sr. Scientist, Chemical Biology)

Inference: three chemistry postings ask for hit-to-lead and lead optimization work on IPM compounds, which suggests the company is optimizing bifunctional molecules toward development candidates.

Cell-based mechanism and proximity biology moderate signal

Today: The site describes targeting 'effector proteins', including 'post-translational modification (PTM) readers/writers/erasers'.

Roles: Scientist, Mechanistic Biology · Scientist/Sr. Scientist, Chemical Biology · Lab Manager

Requirements mention: "BRET", "PTM analysis", "co-IP/pull-down assays" and "global proteomics" (Scientist, Mechanistic Biology) · "co-immunoprecipitation" and "stable cell line generation" (Scientist/Sr. Scientist, Chemical Biology) · "immunoprecipitation assays" and "flow cytometry/cell sorting" (Lab Manager)

Inference: biology hiring centres on showing in cells that compounds bring targets and effector proteins together, and on measuring the resulting protein modifications.

Computational design for IPM compounds weak signal

Today: "We've built the first generalized, mechanism-agnostic, proximity discovery engine."

Roles: Scientist/Sr. Scientist, Computational Chemistry

Requirements mention: "generative chemistry" and "AI/ML" (Scientist/Sr. Scientist, Computational Chemistry) · "FEP/free-energy methods" and "multi-parameter optimization" (Scientist/Sr. Scientist, Computational Chemistry) · "computational chemistry" (Scientist, Medicinal Chemistry; Sr. Scientist/Principal Scientist, Medicinal Chemistry)

No inference drawn: there is one dedicated posting, though both medicinal chemistry postings also list computational chemistry as a requirement.

DMPK and preclinical PK work on IPM candidates moderate signal

Today: IPM drug candidates from the company's proximity discovery engine (OmniTAC), per the site and postings.

Roles: Scientist/Sr. Scientist, DMPK · Sr. Scientist/Principal Scientist, Medicinal Chemistry

Requirements mention: "IND-enabling DMPK studies" and "FIH dose projection" (Scientist/Sr. Scientist, DMPK) · "DMPK studies" and "plasma protein binding" (Sr. Scientist/Principal Scientist, Medicinal Chemistry)

Inference: the DMPK posting asks for IND-enabling study and first-in-human dose projection experience, which suggests the company expects to take candidates into IND-enabling studies.

Where the headcount is going

Department	Open
Chemistry Team	5
Discovery Biology	1
Operations	1
Other	1

Five of the eight listings are Chemistry Team roles, so hiring is weighted toward designing and optimizing compounds; one listing, 'Other Positions', is a general application open since September 2024 rather than a specific role.

Who they need

Seniority: 5 mid-level, 2 senior, 1 with no seniority stated (the general 'Other Positions' listing).

Skills named most: medicinal chemistry, hit-to-lead, lead optimization, SAR, PROTACs, induced proximity medicines, computational chemistry, molecular dynamics, PK/PD, cell-based assays, mammalian cell culture, metabolic stability

Locations: All 8 listings are in San Francisco, CA. None are listed as remote.

You'd fit if you have medicinal chemistry, SAR and hit-to-lead or lead optimization experience, ideally with PROTACs, and are based in San Francisco, CA (Scientist, Medicinal Chemistry; Sr. Scientist/Principal Scientist, Medicinal Chemistry).
You'd fit if you run cell-based mechanism assays such as BRET, co-IP/pull-down and global proteomics and are based in San Francisco, CA (Scientist, Mechanistic Biology).
You'd fit if you have DMPK experience including IND-enabling DMPK studies and FIH dose projection, and are based in San Francisco, CA (Scientist/Sr. Scientist, DMPK).

How to use this

If you're applying: Seven specific roles are open across chemistry, biology, DMPK and lab operations, all in San Francisco, CA, and none are listed as remote. No roles have opened since 2026-07-29, so confirm a role is still active before applying. If no role matches, the 'Other Positions' listing accepts general applications.

If you're selling or recruiting: There are 8 listings: 7 specific roles plus a general 'Other Positions' listing. Five sit in the Chemistry Team, and all are on-site in San Francisco. No roles opened or closed in the last 30 days or the 30 before. The newest postings date from 2026-07-29, and the Chemical Biology role has been open since 2025-09-26. The longest-open chemistry, chemical biology and DMPK roles are the clearest place to offer candidates. The company describes itself as a seed-stage startup.

Open roles (8)

Title	Department	Location	Posted
Scientist/Sr. Scientist, DMPK	Chemistry Team	San Francisco, CA	2026-07-29
Scientist/Sr. Scientist, Computational Chemistry	Chemistry Team	San Francisco, CA	2026-07-29
Scientist, Medicinal Chemistry	Chemistry Team	San Francisco, CA	2026-05-29
Scientist, Mechanistic Biology	Discovery Biology	San Francisco, CA	2026-05-29
Sr. Scientist/Principal Scientist, Medicinal Chemistry	Chemistry Team	San Francisco, CA	2026-04-23
Lab Operations Manager	Operations	San Francisco, CA	2026-02-18
Scientist/Sr. Scientist, Chemical Biology	Chemistry Team	San Francisco, CA	2025-09-26
Other Positions		San Francisco, CA	2024-09-17